NleC |
NleE |
Neuromedin U-8 |
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[non-LEE-encoded effector D] NleD is found in enteropathogenic and enterohemorrhagic Escherichia coli. NleD is one of several gene encoding virulence factors. The term refers to the fact that these genes and a large group of other pathogenicity-related genes are not encoded by a pathogenicity island in chromosome known as the LEE [locus of enterocyte effacement] (for overview see also: Dean and Kenny, 2009).
NleD is injected into cells (Marchés O et al, 2005). Baruch et al (2011) have reported that NleD blocks inflammation responses. NleD is a Zn-dependent endopeptidase that specifically clips and inactivates c-Jun N-terminal kinase (JNK) pathways. Together with other injected effectors such as NleB, NleC, and
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