NLARVPKLDL |
NleC |
C56 |
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[non-LEE-encoded effector B] NleB is found in enteropathogenic and enterohemorrhagic Escherichia coli. NleB is one of several gene encoding virulence factors. The term refers to the fact that these genes and a large group of other pathogenicity-related genes are not encoded by a pathogenicity island in chromosome known as the LEE [locus of enterocyte effacement] (for overview see also: Dean and Kenny, 2009).
The pathogen inhibits inflammation responses of the host by injecting NleB into host cells. NleB blocks the activation of NF-kappa-B activation mediated by TNF-alpha, upstream to IKK-beta activation and hence blocks the NF-kappa-B
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