NleB |
NleD |
immune-induced peptide 21 |
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[non-LEE-encoded effector C] NleC is found in enteropathogenic and enterohemorrhagic Escherichia coli. NleC is one of several gene encoding virulence factors. The term refers to the fact that these genes and a large group of other pathogenicity-related genes are not encoded by a pathogenicity island in chromosome known as the LEE [locus of enterocyte effacement] (for overview see also: Dean and Kenny, 2009).
NleD is injected into cells (Marchés O et al, 2005). The main target of NleC is transcription factor NF-kappa-B, the downregulation and degradation of which blocks inflammation responses because the NF-kappa-B pathway regulates the expression of genes associated with inflammation
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