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NR4

NR4 is a murine receptor identified by Hilton et al (1996) by virtue of sequence similarity to with members of the hemopoietin receptor family. NR4 has been shown to encode the alpha chain of the IL13 receptor (designated IL13RA, IL13RA1), which is capable of binding IL13 with low affinity, but does not bind IL4, IL2, IL9, or IL15. Expression of NR4 in CTLL-2 cells results in the formation of a high affinity IL13 receptor and renders the cells susceptible to the proliferative signal elicited by IL13.

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