MPPs

[multipotential progenitors; multipotent progenitors] This term refers to a class of hematopoietic stem cells that have lost their self-renewal capacity but remain multipotent and thus can differentiate into all mature cell types found in the blood. MPPs express the stem cell antigen Sca-1, high levels of the SCF receptor kit, and the flt-2 receptor (Adolfsson et al, 1992; Christensen and Weissman, 2001). MPPs arises from a more primitive cell type referred to as possessing the phenotype of LSK cells. MPPs differentiate into CLPs [common lymphoid progenitors cells ... ... ... ...
 
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Entry last modified: March 2020