MIP-2-gamma

[macrophage inflammatory protein-2-gamma] The cDNA for this secreted factor was isolated from human dendritic cells. The protein is a member of the CXC-Chemokines. It shares greatest homology with MIP-2-alpha and MIP-2-beta. Murine and human MIP-2-gamma are highly homologous.

MIP-2-gamma is expressed constitutively in most normal tissues with the greatest expression in kidney (epithelium of tubules). Hepatocytes in the liver also express the factor. Expression is not detected in most tumor cell lines except the human myelomonocytic cell line THP-1.

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Entry last modified: January 2002