MHM6

The monoclonal antibody (IgG1) of this name has been raised against Epstein-Barr virus-transformed lymphoblastoid cells (EB-LCL) and recognizes a cell surface antigen associated with the EB virus-transformed state (Rowe et al, 1982). The corresponding antibody reacts with CD23 (Moldenhauer et al, 1987).

Gordon et al (1986) have reported that MHM6 has a costimulatory effect on tonsil B-cells in the presence of phorbol ester. Binding of the antibody to the p45 moiety of CD23 results in the release of a 35 kDa form of the antigen into the conditioned medium of cells (Guy and Gordon, 1987). This shed fraction of CD23 can be recovered also from supernatants of EBV-transformed B-cells and has been shown to have ... ... ... ...
 
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