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Phorbol esters

[Phorbol ester]

Phorbol esters are tumor-promoting compounds originally detected in oil prepared from seeds of Croton tiglium. Some esters, such as phorbol 12-myristate 13-acetate (abbr. PMA) or 12-O-tetradecanoyl-phorbol-13-acetate (abbr. TPA) have highly pleiotropic effects on cells in culture and on tissues in vivo and are used frequently in immunology as activators of T-cells and polyclonal B-cell activators in vitro.


formula of phorbolester


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