MDBK

Madin-Darby bovine kidney cells (ATCC CCL 22). This spontaneously transformed continuous epithelial cell line is used to assay human IFN-alpha which is quantified by performing a cytopathic effect inhibition assay of vesicular stomatitis virus. The cells secrete Insulin-like growth factor binding protein IGFBP2 (see: IGFBP) into the conditioned medium.

Treatment of MDBK cells with human IFN-alpha-2 (see: IFN-alpha) results in a dose-dependent inhibition of cell growth and decreases the number of cell surface EGF receptors and a reduction in the affinity of EGF for its receptor. ... ... ... ...
 
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Entry last modified: January 2002