IGFBPs

[Insulin-like growth factor binding proteins] also abbr. IGBP or IBP. IGFBPs are found in various body fluids such as blood serum, amniotic fluid, and liquor. They are synthesized in the liver and are produced also by various tumor cell lines and cell types. Some cells produce and secrete some IGFBPs constitutively and the synthesis of some IGFBPs is regulated, among other things, by the two different IGF factors themselves. The two forms of IGF also appear to promote directly the proteolytic degradation of some IGFBPs (IGFBP4) into fragments that do not bind IGF, thus providing a mechanism by which each form of ... ... ... ...
 
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Entry last modified: April 2005