MACF1 |
MACH1 |
HCASMC |
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[MORT-associated CED3 homolog] MACH has been identified as a component of the death-inducing signaling complex associated with the FAS antigen (see: APO-1) and the TNF receptor p55. MACH has been shown to bind to another signaling component called FADD. Multiple isoforms of MACH have been observed. Some isoforms contain a region that has proteolytic activity and shows marked sequence homology to the family of cysteine proteases related to IL1-beta Convertase (see also: Caspases). MACH is identical with Caspase-8.
Cellular expression of the proteolytic MACH isoforms results in cell death by apoptosis
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