M33

[MCMV M33; murine cytomegalovirus M33] This protein is encoded by an open reading frame in the genome of murine cytomegalovirus (Rawlinson et al, 1996; Davis-Poynter et al, 1997). The gene encodes a G-protein-coupled receptor which has been shown to function as a receptor for the chemokine RANTES and promotes virus-induced migration of vascular smooth muscle cells (Melnychuk et al, 2005). For a related gene see: U12. Human cytomegalovirus contains a homolog of M33, which can partially compensate for the lack of M33 in vivo, suggesting conserved biological roles (see: UL33). Farrell et al (2011) have demonstrated that US28 ... ... ... ...
 
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Entry last modified: January 2013