LGL1
[late gestation lung 1; late gestation lung protein 1] The gene encoding this secreted glycoprotein (Oyewumi et al, 2003) has been identified in a search for glucocorticoid inducible genes that regulate lung development in late gestation. LGL1 shows 81 % homology to P25TI, a polypeptide trypsin inhibitor identified in human glioblastoma and neuroblastoma cells but not detected in normal human tissues (Kaplan et al, 1999). The sequence contains an LCCL module of unknown function.
LGL1 is expressed in human, rat, and mouse fetal lungs, induced by glucocorticoid, developmentally regulated in fibroblasts. The protein is not detectable in epithelial cells
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