LDECF

[lymphocyte-derived eosinophil chemotactic factors] These biochemically uncharacterized factors of approximately 45-60 kDa were isolated from human T-lymphocytes expressing the CD4 antigen.

LDECF-PD (pI 7-8) is derived from patients with parasite disease. Its production depends on antigen or mitogen stimulation.

LDECF-HES (pI 6) is derived from patients with hypereosinophilic syndrome (HES). Its synthesis does not require stimulation of cells.

Both factors are chemotactic for eosinophils from healthy individuals (see also: Chemotaxis). Eosinophils ... ... ... ...
 
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Entry last modified: January 1999