Jagged

A cDNA clone of this name was isolated initially from a rat cDNA gene library (Lindsell et al, 1995). Gray et al (1999) have cloned the gene, which they have called HJ1. Jagged (also named jagged-1 following the identification of jagged-2) is identical with murine Serrate-1. The approved gene symbol is JAG1. The designation JAGL1 has been used also. These genes have been shown to encode transmembrane ligands for vertebrate Notch. Shimizu et al (2000) have shown that Jagged-1 is a ligand for Notch-1, Notch-2 ... ... ... ...
 
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Entry last modified: August 2009