JHP0290

[Helicobacter pylori JHP0290 protein] this Helicobacter pylori protein has been shown to bind to several target cell types (macrophages, human gastric epithelial cell lines, human monocyte-derived dendritic cells, and human neutrophils). In macrophages, it induces cell death by apoptosis and production of the pro-inflammatory cytokine TNF-alpha. Functional inactivation of the JHP0290 gene in H. pylori strain J99 significantly reduces the ability to induce apoptosis and TNF-alpha in macrophages (Pathak SK et al, 2013).

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Entry last modified: October 2022