JCV agnoprotein |
JE |
Humanin-like peptides |
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[JC polyomavirus agnoprotein; JCV agnoprotein] This small protein is encoded in the genome of JC virus, the causative agent of progressive multifocal leukoencephalopathy in humans. Suzuki et al (2010) have reported that agnoprotein possesses properties commonly associated with channel-forming viroporins. The protein forms homo-oligomers, enhances the permeability of cells to the translation inhibitor hygromycin B, and induces the influx of extracellular calcium ions. The activity of agnoprotein causes membrane dysfunction and enhances virus release. Suzuki et al (2012) have reported a role of agnoprotein in virus assembly. JCV agnoprotein
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