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IgE-HRF

[IgE-dependent histamine releasing factor] IgE-HRF produced by lymphocytes of atopic children and present in biological fluids of allergic patients has been purified by MacDonald et al (1995). The protein is identical with the human growth-related tumor protein p23, a protein of Ehrlich ascites tumor cells synthesized preferentially in the exponentially growing tumor (Bohm et al, 1989). p23 is identical with TCTP (translationally controlled tumor protein). The human gene (TPT1) maps to chromosome 13q12-q14 (McDonald et al, 1999).

This factor is responsible for the late response in many patients with allergic diseases (tissue infiltration of basophils, ... ... ... ... ... Subscribe to continue reading! ... ...

 

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