IRH
[intercrine reduced in hepatomas] This factor was identified as a mRNA the expression of which was reduced in differential displays from human hepatocellular carcinoma (Shibuta et al, 1997). IRH is equivalent to one of the Alpha-Chemokines, SDF-1-alpha (PBSF). The approved gene symbol is CXCL12. The factor is known also as SCYB12. Numerous splice variants exist (see: CXCL12 and SDF also describing alternative nomenclature).
Expression of IRH has been found to be reduced in the majority of gastrointestinal tumors.
This factor is known mainly because of its chemotactic activity. For an unrelated function as an
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