IRF6
[interferon regulatory factor-6] IRF6 is one of several transcription factors that contains a domain called SMIR (SMAD-IRF-binding domain) found also in IRF3 and IRF7 (see also: SMAD, IRF). The human gene maps to chromosome 1q32-q41 (Kondo et al, 2002). Mutation in the IRF6 gene have been causaly related to van der Woude syndrome (hence the occasional abbreviation databanks as VWS1 [van der Woude syndrome 1], an autosomal dominant form of cleft lip and palate (Kondo et al, 2002). The gene is being referred to also as OFC6 [Orofacial cleft 6].
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