IRF3

[interferon regulatory factor-3] The sequence of the transcription factor IRF3 was obtained by searching an EST database for sequences similar to IRF1 and IRF2 (Au et al, 1995).

IRF3 is a protein of 50 kDa that binds specifically to ISRE [interferon-stimulated response element]. The protein contains a domain called SMIR (SMAD-IRF-binding domain) found also in IRF6 and IRF7.

IRF3 has been shown to be a component of a positive regulator of gene transcription stimulated by interferons that functions as a direct response to viral infection (DRAF1; double-stranded RNA-activated factor-1 ... ... ... ...
 
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Entry last modified: January 2002