SMAD

[Sma and Mad related proteins] SMADs are evolutionarily conserved proteins identified as mediators of transcriptional activation (for overview see: Massagué J et al, 2005). SMAD proteins are involved in signaling processes elicited through cell surface receptors of various members of the large family of proteins related to TGF-beta, which includes activins, inhibins, bone morphogenetic proteins, and MIS [Müllerian inhibiting substance] (Heldin et al, 1997). Upon activation, these proteins directly translocate to the nucleus where they may activate transcription (Datto and Wang, 2000). Some SMAD proteins have been shown to interact with SARA and other proteins, mediating the effects of ... ... ... ...
 
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Entry last modified: May 2009