IM33 |
IMAC |
Trophoblast protein-1 |
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This compound, 2-(1H-Indol-3-yl)-3-pentylamino-maleimide, has been identified by Dodo et al (2005) as a potent inhibitor of cell death. IM-54 inhibits necrotic cell death induced by hydrogen peroxide, but not apoptotic cell death induced by etoposide. Thus IM-54 is considered a selective inhibitor of necrosis and is therefore distinct from caspase inhibitors such as zVAD, which can block apoptotic cell death, but not necrotic cell death.
For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.
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