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IDECs

[inflammatory dendritic epidermal cells] Wollenberg et al (1996) have identified this cell type as a distinct population of epidermal cells different from classical Langerhans cells. The cells are CD1a(dim) CD1b(dim) Fc-epsilon RI (bright) CD23(dim) CD32(dim) HLA-DR (bright) CD36(bright). The cells appear in the epidermis of lesional atopic eczema skin and is subjected to specific signals leading to the upregulation of Fc-epsilon-RI in atopic eczema skin. Fc-epsilon RI expression on CD1a(+) cells correlate significantly with the serum IgE level of the patients.

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