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HBP23

[heme-binding protein 23 kDa] This heme binding protein of 23 kDa has been purified from rat liver cytosol by Iwahara et al (1995). The protein binds heme with an affinity (Kd = 55 nM) higher than that of the abundant cytosolic heme-binding proteins, heme-binding protein (HBP)/liver fatty acid-binding protein (L-FABP) and the glutathione S-transferases (Kd = 100-200 nM). The cloned cDNA encodes a protein of 199 amino acids. HBP23 is highly homologous to MSP23 [macrophage 23 kDa stress protein], which is inducible by oxidant stress in peritoneal macrophages (Ishii et al, 1993), and both proteins are identical with PRDX1 [peroxiredoxin-1] (see: NKEF [ ... ... ... ... ... Subscribe to continue reading! ... ...

 

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