HB-EGF
[Heparin binding EGF-like factor, Heparin binding EGF-like growth factor; heparin binding EGF] abbr. also Hegfl]. This factor is found in the conditioned medium of the cell line U937 and is synthesized also by macrophages (Higashiyama et al, 1991), vascular endothelial cells (Yoshizumi et al, 1992), human and rat vascular smooth muscle cells (Diuz et al, 1993; Temizer et al, 1992; Abraham et al, 1993), and keratinocytes. Its expression in neutrophils is upregulated specifically by GM-CSF (Vinante et al, 1999). HB-EGF has been identified in rat
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