GRAM |
GRAM domain |
CG18090 |
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(approved gene symbol) [GRAM domain-containing protein 4] The cDNA for this protein has been identified independently as KIAA0767. The protein has been identified as a target gene for transcription factor E2F1 by Stanelle et al (2002). Stanelle et al (2005), who referred to the protein as DIP [death-inducing protein], have reported the gene structure and have localized the protein to mitochondria. The protein contains a GRAM domain. GRAMD4 has been shown to play a role as a mitochondrial effector of apoptosis. Overexpression shows that GRAMD4 greatly reduces cell viability in several in vitro systems accompanied by typical apoptotic features such as caspase-3 activation and cleavage of
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