GTRCQVAGWGSQRSGGRLSRFPRFVNV |
GTSTGSTDYEPTDVGGEDYDVDESDEDGKA |
Beta-Chymases |
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[Glioblastoma-derived T-cell suppressor factor] This factor is found in the conditioned medium of the human glioblastoma cell line 308 (Schwyzer and Fontana, 1985), which also constitutively secretes a soluble factor with biologic and biochemical characteristics of human IL1 from monocytes.
G-TsF inhibits the effects of IL1 and IL2 on T-lymphocytes. It inhibits the lectin induced proliferation of thymocytes, the proliferation of T-cells induced by IL2 and the development of alloreactive cytotoxic T-cells (Siepl et al, 1988; Kuppner et al, 1989).
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