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Ft1

[fused toes] A dominant mouse mutation (designated Ft) characterized by partial syndactyly of the limbs and thymic hyperplasia, which are the result of impaired regulation of cell death by apoptosis (van der Hoeven et al, 1994). The Ft gene and the human homolog have been cloned by Lesche et al (1997).

Remy and Michnick (2004) have reported that human Ft1 binds to serine/threonine kinase protein kinase B (AKT1) and modulates its activity. This greatly increases the apoptosis susceptibility of T-lymphocytes ... ... ... ... ... Subscribe to continue reading! ... ...

 

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