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Fibulin-5

abbr. FBLN5. The protein is identical with DANCE [developmental arteries and neural crest EGF-like] and has been described also as EVEC [embryonic vascular EGF-like repeat-containing protein].

Fibulin-5 is an extracellular matrix protein that can bind integrins. It is expressed abundantly in great vessels and cardiac valves during embryogenesis, and in many adult tissues abundant in extracellular elastic fibers that provide mechanical elasticity to tissues and contribute towards the processes of organ remodelling by affecting cell-cell signaling.

Fibulin-5 is a calcium-dependent, elastin-binding protein that localizes to the surface of elastic fibers in vivo and regulates their assembly and organization (Yanagisawa et al, 2002). Fibulin-5 interacts with ... ... ... ... ... Subscribe to continue reading! ... ...

 

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