Factor D |
Factor-dependent cell progenitors |
Scribble |
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[factor-dependent cell line]
Established cell lines that entirely depend for their survival and proliferation on the continuous presence of one or more of growth factors (Ihle and Askew, 1989; Mire-Sluis and Thorpe, 1998; Drexler et al, 1997). Factor-dependent cell lines are capable of continuous growth in the presence of the growth factors and cytokines they require (see also: Colony formation assay; Delta assay; BMC). Withdrawal of the growth factors required for proliferation and/or survival usually leads to cell death by apoptosis.
Factor-dependent cell lines have been instrumental in analyzing in detail the processes leading to cell death
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