FSP1

[ferroptosis suppressor protein 1] this term refers to a protein identified by Doll et al (2019) who reported that FSP1 confers protection against cell death by ferroptosis elicited by deletion of GPX4 [glutathione peroxidase 4], a central regulator that counteracts ferroptosis. The effects of FSP1, like that of another endogenous ferroptosis inhibitor, GCH1 [GTP cyclohydrolase 1], are entirely independent of GPX4.

Sequence analysis shows that FSP1 is identical with AIFM2 [apoptosis inducing factor mitochondrion associated 2; mitochondrion associated apoptosis inducing factor-2], which is the same as AMID ... ... ... ...
 
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Entry last modified: October 2022