COPE Media Kit

Cope Home
Previous entry:
Next entry:
GQ1c antigen
Random entry:
bone morphogenetic protein receptor 2
Search COPE:


[glutathione peroxidase 4] GPX4 is a ubiquitously expressed (Baek et al, 2007) selenoprotein oxidoreductase enzyme (197 amino acids, 19 kDa) that associates with membranes, cytoplasm, and mitochondria (Januel et al, 2006) and directly reduces phospholipid hydroperoxides within membranes and lipoproteins, using glutathione as a cofactor. It acts in conjunction with alpha-tocopherol (vitamin E) to inhibit lipid peroxidation (Scheerer et al, 2007). Only GPX4 reduces cholesterol and complex membrane lipid hydroperoxides (Ursini et al, 1985; Thomas et al, 1990).

The human cDNA has been cloned by Esworthy et al (1994), who referred to it as PHGPX [Phospholipid hydroperoxide glutathione peroxidase]. Kelner and Montoya (1998) have reported the structure of the human GPX4 gene. ... ... ... ... ... Subscribe to continue reading! ... ...


Content view restricted !

COPE - with 54500+ entries the most comprehensive cell-to-cell communication knowledge base

Extensive In-depth and In Context Information covering terminology, nomenclature, concepts, strategies & complexities of cellular communication, including Acute phase proteins | Angiogenesis | Antimicrobial & host defense peptides | Apoptosis & other forms of cell death | CD antigens | Cell lines | Cell reprogramming | Chemokines | Cryptides | Cytokines & Growth factors | CytokineTopics | Eukaryotic cell types & expression profiles | Hematopoiesis | Hormones | Inflamation & inflammatory mediators | Innate Immunity | Metalloproteinases | Microvesicles / Microparticles | Moonlighting proteins & cryptides | Neuropeptides | Non-coding RNAs | Pathogenicity & Virulence Factors | Pattern recognition receptors | Peptide sequences | Protein domains | Regulatory peptide factors | Viroceptors | Virokines and more.

Full COPEing for subscribers:

Access to Alphabet bar, Freetext search, Leafing/browsing functions, Internal Backlinking, Topic-specific introductions, Topic-specific integrated subdictionaries, Scientific references with PubMed links

with a 15 USD/month subscription at

See example pages at the bottom of the home page
The others just sisyphos around


Copyright © 1997-2021. All rights reserved by Dr H Ibelgaufts, the author of COPE - Cytokines & Cells Online Pathfinder Encyclopaedia


SUPPORT COPE | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials
# A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

              Created, developed, and maintained by Dr H Ibelgaufts              
About the author of COPE
  |    Contact COPE   |    Terms & Conditions

U L T R A   P O S S E    N E M O   O B L I G A T U R

cope.cgi Version 1.41 [08.12.2020]. (c) JI. Powered by Perl 5.028001. key=22113