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FLICE-2

[FADD-like interleukin-1 beta-converting enzyme-2] FLICE-2 is a member of the family of caspases and identical with MCH4. The enzyme is known now as Caspase-10. It shows an overall architecture and function similar to that of FLICE. The carboxyl-terminal half of the small catalytic subunit that includes amino acids predicted to be involved in substrate binding is distinct. The pro-domain of FLICE-2 encodes a functional death effector domain that binds to the corresponding domain in the adapter molecule FADD (Vincenz and Dixit, 1997). FLICE-2 is recruited to both the CD95 and p55 TNF receptor signaling complexes and this complex formation is enhan ced by FADD ... ... ... ... ... Subscribe to continue reading! ... ...

 

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