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Escherichia coli Cytolethal distending toxin

This toxin is produced by a limited number of Escherichia coli isolates and various other bacterial species (see: CDT) (Pickett et al, 1994; Scott and Kaper, 1994). The toxin is cytolethal to Vero, HeLa, HEp-2 and CHO cells and causes progressive cell distention and cytotoxicity. This is a three-component toxin that induces the irreversible arrest of the mammalian cell cycle in the G2 phase, and ultimately causes cell death by apoptosis. Comayras et al (1997) have reported that the toxin causes cell accumulation in the G2 phase and not the M phase of the cell cycle ... ... ... ... ... Subscribe to continue reading! ... ...

 

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