East Lansing Tyrosine Kinase |
eat-me signals |
defensin-alpha-28 |
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This transmembrane protein from Drosophila melanogaster, encoded by gene CG6124, has been identified by Kocks et al (2005). The Eater protein is expressed in blood cells and functions as a pattern recognition receptor and phagocytic receptor for various Gram-positive bacteria and Gram-negative bacteria. Microbial recognition by Eater involves a direct interaction between its N-terminal four EGF-like repeats and microbial surfaces (Kocks et al, 2005). Microbial binding to the Eater protein can be inhibited with scavenger receptor ligands, acetylated, and oxidized low-density lipoprotein.
Transcriptional silencing of the eater gene in a macrophage cell line
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