ELAM |
ELAM-1 ligand fucosyltransferase |
Gram stain |
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[endothelium leukocyte adhesion molecule 1] ELAM-1 (also: ELAM) is a cell surface glycoprotein expressed by cytokine-activated endothelium and mediates the adhesion of blood neutrophils. The expression of ELAM-1 in cultured human endothelial cells is induced by cytokines.
The gene encoding this protein has been cloned by Bevilacqua et al (1989). It is related to the MEL-14 lymphocyte cell surface homing receptor, and GMP-140, a membrane glycoprotein of platelet and endothelial secretory granules. In the nomenclature of CD antigens the new designation of this protein is
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