EDKPFWPPPIYPM |
EDMF |
Penaeus vannamei hemocyanin C-terminal fragment |
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[Endothelial cell-derived lymphocyte chemotactic activity] This biochemically uncharacterized factor of approximately 13-15 kDa was detected originally in the conditioned medium of serotonin-stimulated bovine aortic endothelial cells.
Based on its physicochemical and functional characteristics and antibody inhibition studies, ED-LCA is distinct from previously identified endothelial cell-derived factors such as IL1, IL6, and IL8.
ED-LCA is a chemoattractant for CD4(+) CD8(+) T-lymphocytes and does not enhance the migration of neutrophils or monocytes. (see also: Chemotaxis,
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