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Densin-180

Densin-180 is a brain-specific synaptic protein of 180 kDa found in the postsynaptic density, an electron-dense thickening just beneath the postsynaptic membrane (Apperson et al, 1996). Densin-180 contains 17 copies of an LRR domain, a sialomucin domain, a transmembrane domain, and a PDZ domain. A splice variant of the protein, termed LRRC7, has been shown to contain a nuclear localization sequence and four copies of an LRR domain (Wang et al, 2003). Densin-180 is the founding member of the family of LAP proteins, which are involved in the formation of complex protein networks that maintain the architecture of epithelial cells.

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