DAB389IL2 |
Dacar |
Haptoglobin |
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This peptide has been isolated from the hemotoxic venom of the snake Daboia mauritanica (Chalier et al, 2020). It is related to the disintegrin Lebein-1 isolated from Macrovipera lebetina venom, and the authors also referred to Dabmaurin-1 as Lebein-1-Like.
Dabmaurin-1 inhibits the proliferation of endothelial cells (human dermal microvascular endothelium cells) without any significant cytotoxicity and disrupts interactions of these cells with extracellular matrix proteins involved in angiogenesis. Dabmaurin-1 is a strong inhibitor of the receptors of fibronectin, fibrinogen, vitronectin,
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