DR6

[death receptor-6] This protein belongs to the TNF receptor superfamily. The new designation is TNFRSF21 [TNF receptor superfamily member 21]. Mouse and human protein sequences show approximately 88 % identity (Pan et al, 1998). In the nomenclature of CD antigens this protein has been given the designation CD358.

DR6 is a type 1 transmembrane receptor, possesses four copies of an extracellular cysteine-rich motif and a cytoplasmic death domain known to signal apoptosis. DR6 is expressed in most human tissues. It interacts with TRADD, which has previously been shown to associate with ... ... ... ...
 
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Entry last modified: April 2018