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DING protein

This protein is identical with SSP [synovial stimulating protein] isolated from rheumatoid arthritis synovial fluid and from the conditioned medium of rheumatoid arthritis synovial fibroblasts (Hain et al, 1996). Adams et al (2002) have shown that SSP is immunologically cross-reactive with hirudin-binding protein, a protein of a 40 kDa isolated from skin fibroblast cultures and produced by normal and rheumatoid arthritis fibroblasts in culture, and also by cervical carcinoma cells. Belensky et al (2003) have identified the protein by virtue of its ability to bind to genistein.

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