DF3

[Breast carcinoma-associated antigen DF3]The murine monoclonal antibody designated DF3 has been prepared prepared against a human breast carcinoma metastatic to liver (Kufe et al, 1984) and defines a high molecular weight antigen detectable in human breast carcinomas and in human milk (Sekine et al, 1985; Abe and Kufe, 1987). The same protein has been identified by a monoclonal antibody recognizing MSA [mammary serum antigen]. DF3 monoclonal antibody detects the 20 amino acid sequence of the epithelial mucin MUC-1 [mucin 1] (Bara et al, 1993).

Hayes et al (1990) have suggested that the DF3 antigen acts as an immunomodulating agent and may serve to protect secretory ... ... ... ...
 
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