DDX60

[DEAD box polypeptide 60] This protein, which contains a DEAD box and is a cytoplasmic RNA helicase, has been implicated in innate immunity (for a related factor see: DDX60L).

DDX60 expression is upregulated in human dendritic cells during infection with measles virus. DDX60 is required for type 1 interferon expression after DNA virus infection (vesicular stomatitis virus, Poliuovirus). After viral infection, the DDX60 binds to endogenous RIG-I protein. The protein also binds to MDA-5 and LGP2. Expression of DDX60 promotes the binding of RIG-I to double-stranded RNA. Purified DDX60 helicase domains ... ... ... ...
 
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Entry last modified: August 2015