Corneoptosis

also often simply cornification although this process usually refers to the entire process of forming the outermost skin barrier. The term Corneoptosis has been used to refer to a specialized form of cell death observed in epidermal keratinocytes in the granular layer to form flattened dead cells in the stratum corneum, the topmost layer of the epidermis, forming the protective skin barrier.

Granular layer cell death involves a sequence of distinct intracellular ionic alterations beginning with an early phase of elevated Ca2+ levels and a neutral pH followed by a phase of persistently high Ca2+ concentration and a shift to an acidic pH. Subsequently, this is followed by the dissolution of keratohyalin granules, the degradation of nuclear DNA ... ... ... ...
 
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Entry last modified: March 2024