Cachectin

A protein, initially found to be secreted by macrophages, that in vitro suppressed the expression of enzymes of lipid metabolism in adipocytes and induced a cachectic state in vivo caused by systemic suppression of the enzyme lipoprotein lipase (LPL) (Beutler et al, 1985; Beutler and Cerami, 1988).

Beutler B et al (1985) have shown that cachectin derived from macrophages is identical with TNF-alpha. The importance of this factor is illustrated by the observation that passive immunization against cachectin protects mice from lethal shock caused by bacterial endotoxin.

For another factor suppressing lipoprotein lipase expression see also: Cachexia inducing factor.

The term cachectin is still in use as a general term for ... ... ... ...
 
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