CGFELETC |
CGGKVGKACCVPTKLSPISVLYK |
cellular fibronectin |
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This peptide has been identified by Karjalainen K et al (2011) through phage display selection. The peptide binds to different leukemia cell lines and to patient-derived bone marrow samples. and functions as a cancer-targeting peptide that is internalized through a pathway involving the Neuropilin-1 receptor, which is a high-affinity receptor for the three semaphorins Semaphorin 3, Semaphorin E, and Semaphorin 4 and an isotype specific receptor for VEGF-165. A fusion peptide of CGFYWLRSC with the pro-apoptotic and cytotoxic KLAKLAK sequence has a potent anti-leukemia cell effect. The authors have reported increased expression of
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