CCBE1
[collagen and calcium binding EGF domains 1] The gene encoding CCBE1 has been cloned independently as KIAA1983 and has been termed also Full of fluid protein homolog, which is the counterpart of zebrafish fof [full of fluid]. The protein is secreted.
Role in lymphangiogenesis
Facucho-Oliveira J et al (2011) have reported that CCBE1 expression marks the cardiac and lymphatic progenitor cell lineages during early stages of mouse development.
Mutations in the CCBE1 have been shown to be responsible for Hennekam lymphangiectasia-lymphedema syndrome (Alders et al, 2009), a form of
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