BIT |
bite cells |
ESOP-1 |
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[BCL2 inhibitor of transcription 1] The approved gene syombol for this protein is PTRH2 [peptidyl-tRNA hydrolase 2]; abbr. also: PTH2.
This mitochondrial protein has been identified by Jan et al (2004) in a search for proteins involved in cell adhesion-dependent regulation of anoikis, a form of cell death caused by loss of cell attachment to the extracellular matrix. Bit1 is released into the cytoplasm during apoptosis. Cytoplasmic Bit1 forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein, and induces cell death with characteristics of apoptosis independent of the activity of caspases. Cell attachment to
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