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Bit1

[BCL2 inhibitor of transcription 1] The approved gene syombol for this protein is PTRH2 [peptidyl-tRNA hydrolase 2]; abbr. also: PTH2.

This mitochondrial protein has been identified by Jan et al (2004) in a search for proteins involved in cell adhesion-dependent regulation of anoikis, a form of cell death caused by loss of cell attachment to the extracellular matrix. Bit1 is released into the cytoplasm during apoptosis. Cytoplasmic Bit1 forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein, and induces cell death with characteristics of apoptosis independent of the activity of caspases. Cell attachment to ... ... ... ... ... Subscribe to continue reading! ... ...

 

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