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Bak

The Bak antigen has been identified originally as an antigen expressed specifically on platelets and involved in neonatal auto-immune thrombocytopenia (von dem Borne et al, 1980). Van der Schoot et al (1986) have identified the antigen as GPIIb (platelet glycoprotein IIb)

The two known alleles, designated Bak(a) and Bak(b) (Kickler et al, 1988), differ in a single amino acid (Bak(a) is leucine-843; Bak(b) is serine-843) (Lyman et al, 1990). The Bak antigen has been shown to be identical with the Lek(a) antigen. In the nomenclature for platelet antigens the designation for this alloantigen is HPA-3 [human platelet antigen-3].

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